A NUMERICAL APPROACH TO ION CHANNEL MODELLING USING WHOLE-CELL VOLTAGE-CLAMP RECORDINGS AND A GENETIC ALGORITHM.

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission.The currently most accurate Embroidery Fabrics method for determining ion channel kinetic mechanisms is single-channel recording and analysis.Yet, the limitations and complexities in interpreting single-channel recordings discourage many physiologis

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Escitalopram-induced skin rash: Dermatitis medicamentosa

Selective serotonin reuptake Concealment Gloves inhibitors (SSRI) are the most prescribed antidepressant medications for the treatment of depression and other psychiatric disorders due to their efficacy, tolerability, and safety profile.The dermatological side-effects or cutaneous reactions due to SSRI class of antidepressants is rare.Though there

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Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities.

Biochemical systems consist of numerous elementary reactions governed by the law of mass action.However, experimentally characterizing all the elementary reactions is nearly impossible.Thus, over a century, their deterministic models that typically contain rapid reversible bindings have been simplified with non-elementary reaction functions (e.g.,

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